Montag, 26. September 2016

Emphysema: Causes, Symptoms and Biological Consequences

The disease causes the air sacs in the lungs, called alveoli, to enlarge. Cell walls are broken down and damaged, resulting in fewer larger damaged air sacs. Thus, the oxygen uptake into the blood and CO2 return is decreased.

Causes:

·         The most important cause is cigarette smoking
·         Air pollution, dust or chemicals
·         Childhood respiratory disorders
·         Low weight

It is caused by an increased level of phagocytes which inflame the wall of alveoli.
The disease can also be congenital (meaning that it is genetically predisposed). People have an alpha1-antitrypsin deficiency.

Symptoms:

·         Shortness of breath
·         Coughing
Minor symptoms:
·         Lung infections
·         Producing mucus
·         Weight loss
·         Fatigue
·         Blue lips and nails
·         Depression
·         Sleep disorder
·         Headache

Biological consequences:

There is an increased level of phagocytes in the alveoli. These normally destroy antigens by engulfing and producing a protein digesting enzyme called elastase, which kills the antigen. An enzyme inhibitor, called alpha 1-antitrypsin normally protects the lung tissue from the elastase by inhibiting the enzyme.
In smokers the number of phagocytes increases, which can therefore inflame the inner wall of the alveoli, because there are not enough inhibitors to inhibit elastase.

Sources:

https://www.google.co.uk/search?q=emphysema&biw=1242&bih=557&source=lnms&tbm=isch&sa=X&ved=0ahUKEwj2qM_g2q3PAhXBvxQKHV_IDi0Q_AUIBigB#imgrc=yQfTRFNQF7dfpM%3A



Lung Cancer: Causes, Symptoms, Biological Consequences

Cancer generally can be defined as out-of-control cell growth.
There are 2 types of tumour, the malignant and the benign tumour. The malignant tumour can spread to other organs of the body, causing secondary tumours to arise. This is more dangerous than a benign tumour which stays at its original location. The process by which a primary tumour is spread in the body to form secondary tumours is called metastasis.

Causes:

Inhalation of carcinogenic substances (x-rays, tobacco, air pollution, chemicals, dust). These are responsible for damaging the DNA. Free radicals form, which want to steal electrons from other body cells and in the process they damage the DNA. Humans can also be born with a predisposition to develop cancer due to a genetic mutation which makes cancer more likely.

Symptoms:

The cancer undermines the lung’s ability to take up oxygen. It tends to block air way paths and tubules. There can also be bleedings. Another sign might be chronic coughing.
  • ·         Coughing intensely
  • ·         Pain in shoulder or chest
  • ·         Changes in coughed up mucus
  • ·         Coughing blood
  • ·         Chronic pneumonia
  • ·         Chronic bronchitis
  • ·         Difficulty breathing
  • ·         Hoarse voice


Biological consequences:

Cancer can occur in 2 situations: either it can spread through the blood by a process called invasion, destroying healthy tissue, or a cell divides and grows and feeds on blood by a process called angiogenesis.

There is small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC)

Examples of NSCLC:

  • Squamous cell carcinoma:
  • ·         Most common
  • ·         Most common in men
  • ·         Forms in lining of the bronchial tubes

  • Ardenocarcinoma:
  • ·         Most common in non-smokers
  • ·         Most common in women
  • ·         Forms in mucus producing glands in the lungs




Sources:
https://www.google.co.uk/search?q=squamous+cell+carcinoma&espv=2&biw=1242&bih=602&source=lnms&tbm=isch&sa=X&ved=0ahUKEwit_YCJ2K3PAhVFKsAKHVc9BU0Q_AUIBigB#imgrc=MLiJCKzMn8aLuM%3A
https://www.google.co.uk/search?q=Adenocarcinoma&espv=2&biw=1242&bih=602&source=lnms&tbm=isch&sa=X&ved=0ahUKEwizqYyP2K3PAhVqI8AKHR76B6cQ_AUIBigB#imgrc=J2z4VMXs7e_2OM%3A



Sonntag, 25. September 2016

Olaf the oxygen malecule and his journey through the human body

Hello I am Olaf, the oxygen molecule and I want to take you around the body and show you my daily life, supporting the human respiratory system...

You can imagine my cycle around the body like a day at work, starting in the morning when I go to my work place. My state from floating around in the air changes because person x inhales my through his mouth. I am sucked into the trachea then, which is like like walking along a street.

This happens because of the change of pressure in the internal body system and the external pressure. The diaphragm moves downwards pushing the abdomen out and the rib cage moves upwards and outwards at the same time, so that the lungs have more space. Thus, there is an increased volume which decreases the pressure inside the lungs, causing the air to be inspired.

So I travel down the pathway from trachea to the lungs, starting with big tubes called bronchi, which separate into smaller tubes called bronchioles which end in little air sacs, called alveoli.

Arrived at the alveoli, now I have to cross the membranes to get to the blood stream, flowing through a network of little blood vessels called capillaries. This is like a crossing over a pedestrian crossing. I have to float through two cell walls, one of the alveoli and one of the capillary, having each two membranes, thus until arriving in the bloodstream crossing a total of four cell membranes, which is a relatively short way for me, making my day less complicated.

Now, I jump onto a red blood cell which will carry me through the stream, like a personal motor boat. Meanwhile I oxygenate the deoxygenated stream. Special about it is, that it is an artery stream, which I travel along in direction of the heart now, which can be imagined like travelling in the opposite direction of the traffic, because normally arteries lead away from the heart. To jump on the boat and to be bound to a hemoglobin molecule, I have to overcome the wall of the red blood cell, which is like opening the door of a car.

The red blood cell takes me to the heart, which is like a junction, where the direction of traffic changes. Now I am pumped together with the red blood cell into a new artery, which brings me to whatever location where engergy is needed. Arrived at any place in the body, I can mix with my colleagues, a few Mr Water and a particular Mr Glucose. Together, we can produce ATP.

This is basically the important bit of my work and afterwards I am really exhaused and I head of into direction of the outside world. Thus, another red blood cell picks me up via a vein. I have to cross its cell wall again then, binding to a carbohemoglobin that is connected to the cell. On the way back, we cross the juction at the heart again leading to another vein that belongs to the pulmonary system, which my day had started with, the circulation to the cells for energy having been the systematic circulation.

The vein takes me back to the lungs where I have to at first get off the blood cell by exiting through its membrane and then cross the four membranes of capillary and alveoli again, ending in the alveoli as a carbon dioxide compound.

Now, the only step that is left, before my final destination, returning to my home, the air, is to be pumped up by exhalation of person x again. Ventilation is activated by the diaphragm, a muscle which relaxes and pushes upward into a domed shape and the rib cage being pulled in and down. I am moves outside through the bronchioles, bronchi and trachea again, finally floating through the mouth and being released into the atmosphere.

This was my daily routine and the formation of O2 into CO2 in the human respiratory system.

Sources:
http://de.slideshare.net/sarahfree/oxygen-through-the-respiratory-system
https://prezi.com/9uqpc_zz4x1l/oxy-the-oxygen-molecules-journey-through-the-respiratory-system/
http://image.slidesharecdn.com/lecture7resp-141208082139-conversion-gate01/95/respiratory-system-7-638.jpg?cb=1418029376




Samstag, 17. September 2016

COELIAC DISEASE - WHAT IS IT ABOUT?

What celiac disease is:

The lining of the small intestine after the immune system has attacked the gluten
It is an autoimmune disorder. This means that the body attacks its own tissue. This results in inflammation of organs which can be really dangerous. Celiac disease affects the gastrointestinal tract, because the body recognizes gluten, found in food such as barley, rye and wheat as a threat to the body and attacks it. While attacking the gluten, the villi in the small intestine get also damaged through the inflammation and are shortened, which means that they decrease in surface area. This means that they can’t absorb nutrients as efficiently anymore and this results in nutrient deficiencies and so on.

Description of the basic cause and symptoms of celiac disease:

Celiac disease is caused by the body’s own immune system, which reacts and attacks the gluten found in the gut. The disease can be caused partly environmentally and partly by genetics and occurs more often in people who already suffer from another disease. It can develop spontaneously and can be unnoticed by the person who has got it. The villi in the small intestine are damaged and thus nutrients can be absorbed properly anymore. This damage in the intestine leads to symptoms such as
·         weight loss due to malnutrition caused by the poor absorption.
·         diarrhoea and abdominal pain and swelling due to the inflammation.
·         food intolerance
·         inflammation increases the risk of gastrointestinal cancers (e. g. cancer of oesophagus or small intestine)
·         iron deficiency due to lack of red blood cells
·         vitamin deficiencies
·         low bone mineral density
·         visible affects: enamel of teeth, chronic fatigue, joint pain, poor growth, delayed puberty, miscarriage and infertility
·         Neurological symptoms: Migraine, depression, ADHD, epilepsy

Explanation of the effect of celiac disease on intestinal villus and how this leads to its symptoms:

The villus is inflamed and thus shortened and flattened so that nutrients cannot pass through it anymore. This causes the cells to be more sensitive so that cancer can be developed. It also means that nutrients such as vitamins cannot be taken up into the blood, so that vitamin 12 and folate deficiency anaemia can be developed. Iron deficiency also causes a lack of red blood cells, leading to other health problems, connected to oxygen transport.

Description of the effect of genetics on a person’s predisposition to celiac disease:

There is a genetic predisposition for the development of the disease and first degree relatives have a 4-15 % chance to inherite the disease, but the inheritance pattern is unknown. The disease seems tobe connected to the disposition of the genetic of a human containing specific variants of the HLA-DQA1 and the HLA-DQB1 genes. These are human leukocyte antigen complexes (HLA). They bond by proteins called antigen-binding DQaß heterodimer, which is a complex that is on the surface of immune cells and attaches to antibodies, which it recognizes as invading.

How celiac disease is currently tested for:

Australian scientists found a method to test the blood for celiac disease in 2014. Generally, people who are genetically predisposed to have the disease are advised to be screened. The diagnosing nowadays involves the taking of the blood sample to search for antibodies that are specific to that disease. When they are found, a biopsy is conducted whereby an endoscope(a tube with light) is passed down the mouth to the small intestine and  a tiny biopsy tool will take samples of the small intestine.

Sources:

https://www.google.co.uk/search?q=picture+of+coeliac+disease&espv=2&biw=1242&bih=606&source=lnms&tbm=isch&sa=X&ved=0ahUKEwiBtsT-iZfPAhUjI8AKHcgnBggQ_AUIBigB#imgrc=ypRXZzd0mYwyCM%3A




TESTING A TRANSPIROMETER

A transpirometer is there for the purpose of measuring plant transpiration. Transpiration can be defined as 'the passage of water through a plant from the roots through the vascular system to the atmosphere'.
The instrument constists of a tube with 3 openings(in one of which the leavy shoots sits). A horizontal thin gradualted cappilary tube is connected to it's horizontal end and leads into a beaker. The beaker controls the constant level of water in the tubes and a reservoir is connected to the system to be able to reset the experiment. The tubes are all filled with water, allowing just one little bubble of air into the capillary tube and sealing the opening to the leavy shoot with a cork and vaseline so that no additional air can come into the system. When the plant transpires, water is supposed to be sucked up by the roots, so that the air bubble will start moving along the graduated caillary tube. The scaling bars on it allow to measure the rate of transpiration.

In my biology class we conducted a set up the transpirometer, the photos of the set up are shown below:

 

http://c1.staticflickr.com/1/458/20406535075_f2432a61b2_n.jpg

http://www.merriam-webster.com/dictionary/transpirometer